Covering: 1980 to end 2014 A diverse range of strategies leading to natural product derived
or inspired screening libraries aims to increase the number of new chemical entities …

Background: The approval of Taxol® in 1993 marked the great entrance of terpenoids in the
anti-cancer area and this drug is still highly important in the treatment of refractory ovarian …

Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have
proved to be a prolific source of bioactive natural products. Among marine-derived …

Multidrug resistance (MDR) to anticancer drugs is a serious health problem that in many
cases leads to cancer treatment failure. The ATP binding cassette (ABC) transporter P …

Dengue is a major public health concern in tropical and subtropical countries of the world.
There are no specific drugs available to treat dengue. Even though several candidates …

Sortase A (SrtA) is an enzyme that catalyzes the attachment of proteins to the cell wall of
Gram‐positive bacterial membrane, preventing the spread of pathogenic bacterial strains …

Cancer-causing nature is one of the toxicological endpoints bringing about the most
elevated concern. Likewise, the standard bioassays in rodents used to survey the cancer …

Background The aim of this study was to investigate the expression of PTK6 in different
groups of triple negative breast cancer and its impact on prognosis. Methods Retrospective …

Highlights•Modern drug discovery efforts are leaning toward natural product-based
scaffolds.•Marine natural products exemplify novel resources for new drugs.•Marine …

Our previous studies showed that several sipholane triterpenes, sipholenol A, sipholenone
E, sipholenol L and siphonellinol D, have potent reversal effect for multidrug resistance …