Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Thyroid hormones (THs) may play a role in diseases other than hyper-and hypothyroidism.
Several lines of evidence suggest tumor-promoting effects of TH and TH receptors. They are …

Calcitriol, the hormonally active form of vitamin D, exerts multiple anti-proliferative and pro-
differentiating actions including cell cycle arrest and induction of apoptosis in many …

The molecular genetic basis of thyroid carcinogenesis is not well understood. Most of the
existing models of thyroid cancer only rarely show metastases, and this has limited progress …

Context: Traditionally, factors predisposing to diseases are either genetic (“nature”) or
environmental, also known as lifestyle-related (“nurture”). Papillary thyroid cancer is an …

BACKGROUND: Thyroid hormone receptors (TRs) are ligand-dependent transcription
factors that mediate the actions of the thyroid hormone (T3) in development, growth, and …

Abstract β-catenin is involved in both cell–cell interactions and wnt pathway–dependent cell
fate determination through its interactions with E-cadherin and TCF/LEF transcription factors …

Context: Loss of the thyroid hormone receptor is common in tumors. In mouse models, a
truncated THRB gene leads to thyroid cancer. Previously, we observed up-regulation of the …

Background Whereas there is increasing evidence that loss of expression and/or function of
the thyroid hormone receptors (TRs) could result in a selective advantage for tumor …