Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …

Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …

Psychosocial maternal stress experienced during different vulnerable periods throughout
gestation is thought to increase the individual's risk to develop neuropsychiatric …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA
double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and …

Radiation-induced chromosomal aberrations represent an early marker of late effects,
including cell killing and transformation. The measurement of cytogenetic damage in tissues …