Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

[HTML][HTML] Diabetic neuropathy

EL Feldman, BC Callaghan, R Pop-Busui… - Nature reviews Disease …, 2019 - nature.com
The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

Diabetic neuropathy: mechanisms to management

JL Edwards, AM Vincent, HT Cheng… - Pharmacology & …, 2008 - Elsevier
Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization

LF Gumy, GSH Yeo, YCL Tung, KH Zivraj, D Willis… - Rna, 2011 - rnajournal.cshlp.org
mRNAs are transported, localized, and translated in axons of sensory neurons. However,
little is known about the full repertoire of transcripts present in embryonic and adult sensory …

Enhancing diabetic wound healing: Advances in electrospun scaffolds from pathogenesis to therapeutic applications

X Jiang, YE Zeng, C Li, K Wang, DG Yu - Frontiers in Bioengineering …, 2024 - frontiersin.org
Diabetic wounds are a significant subset of chronic wounds characterized by elevated levels
of inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species …

Mechanisms of disease: the oxidative stress theory of diabetic neuropathy

C Figueroa-Romero, M Sadidi, EL Feldman - Reviews in Endocrine and …, 2008 - Springer
Diabetic neuropathy is the most common complication of diabetes, affecting 50% of diabetic
patients. Currently, the only treatment for diabetic neuropathy is glucose control and careful …

Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

Y Liu, S Shao, H Guo - Life sciences, 2020 - Elsevier
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that
affects approximately half of patients with diabetes. Current treatment regimens cannot treat …

Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence

M Saheb-Al-Zamani, Y Yan, SJ Farber, DA Hunter… - Experimental …, 2013 - Elsevier
Repair of large nerve defects with acellular nerve allografts (ANAs) is an appealing
alternative to autografting and allotransplantation. ANAs have been shown to be similar to …

A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia

JN Sleigh, GA Weir, G Schiavo - BMC research notes, 2016 - Springer
Background The cell bodies of sensory neurons, which transmit information from the
external environment to the spinal cord, can be found at all levels of the spinal column in …