Orchestration of innate and conditioned defensive actions by the periaqueductal gray
The midbrain periaqueductal gray (PAG) has been recognized for decades as having a
central role in the control of a wide variety of defensive responses. Initial discoveries relied …
central role in the control of a wide variety of defensive responses. Initial discoveries relied …
Different patterns of freezing behavior organized in the periaqueductal gray of rats: association with different types of anxiety
ML Brandão, JM Zanoveli, RC Ruiz-Martinez… - Behavioural brain …, 2008 - Elsevier
Freezing defined as the complete absence of body movements is a normal response of
animals to unavoidable fear stimuli. The present review presents a series of evidence …
animals to unavoidable fear stimuli. The present review presents a series of evidence …
Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze
D Fabris, MC Carvalho, ML Brandão… - Journal of …, 2022 - journals.sagepub.com
Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has
therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only …
therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only …
Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic-and antidepressant-like behaviors
CS Kim, PY Chang, D Johnston - Neuron, 2012 - cell.com
The hippocampus is an integral brain region for affective disorders. TRIP8b knockout mice
lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have …
lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have …
Neural correlates of interactions between cannabidiol and Δ9‐tetrahydrocannabinol in mice: implications for medical cannabis
SM Todd, JC Arnold - British journal of pharmacology, 2016 - Wiley Online Library
Background and Purpose It has been proposed that medicinal strains of cannabis and
therapeutic preparations would be safer with a more balanced concentration ratio of Δ9 …
therapeutic preparations would be safer with a more balanced concentration ratio of Δ9 …
The effects of selective breeding for differential rates of 50‐kHz ultrasonic vocalizations on emotional behavior in rats
Fifty‐kHz ultrasonic vocalizations have previously been shown to be positively correlated
with reward and appetitive social behavior in rats, and to reflect a positive affective state. In …
with reward and appetitive social behavior in rats, and to reflect a positive affective state. In …
Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze
D Drapier, D Bentué-Ferrer, B Laviolle, B Millet… - Behavioural brain …, 2007 - Elsevier
Antidepressants are usually prescribed for the treatment of depression but more recently
have also been recommended for the treatment of anxiety disorders. The purpose of this …
have also been recommended for the treatment of anxiety disorders. The purpose of this …
CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca …
BM de Paula Rodrigues… - Journal of …, 2022 - journals.sagepub.com
Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted
increasing clinical interest and consist in a new perspective for treating some neurological …
increasing clinical interest and consist in a new perspective for treating some neurological …
Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates …
A Uribe-Marino, A Francisco… - …, 2012 - nature.com
Several pharmacological targets have been proposed as modulators of panic-like reactions.
However, interest should be given to other potential therapeutic neurochemical agents …
However, interest should be given to other potential therapeutic neurochemical agents …
Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the …
NC Coimbra, R De Oliveira, RL Freitas, SJ Ribeiro… - Experimental …, 2006 - Elsevier
Deep layers of the superior colliculus, the dorsal periaqueductal gray matter and the inferior
colliculus are midbrain structures involved in the generation of defensive behavior and fear …
colliculus are midbrain structures involved in the generation of defensive behavior and fear …