The regulation of gene expression in living organisms rests mainly upon the recognition of
nucleic acid base sequences by proteins [1, 2]. However, nucleic acids can also play a role …

The nature of fish antibodies (concentrating primarily on the most studied species of bony
and cartilaginous fishes) is discussed in terms of their immunoglobulin biochemistry and …

To characterize proteins that bind to the immunoglobulin (lg) heavy chain and the K light
chain enhancers, an electrophoretic mobility shift assay with end-labeled DNA fragments …

NF-KB is a nuclear protein, found only in cells that transcribe immunoglobulin light chain
genes, that interacts with a defined site in the K immunoglobulin enhancer. This protein can …

In cells that do not express immunoglobulin kappa light chain genes, the kappa enhancer
binding protein NF-κB is found in cytosolic fractions and exhibits DNA binding activity only in …

Heterokaryons provide a model system in which to examine how tissue-specific phenotypes
arise and are maintained. When muscle cells are fused with nonmuscle cells, muscle gene …

We have employed a gel assay to detect a transcription factor in nuclear extracts of
adenovirus-infected cells that interacts with the adenovirus E2 promoter, an ElA inducible …

We have mapped the distribution of the major and minor DNase I-hypersensitive sites in the
human" beta-like-globin" gene domain. The minor DNase I-hypersensitive sites map close to …

Platelet-derived growth factors (PDGFs) are growthregulatory molecules that stlmulate
chemotaxls, pro-Iltiration, and lncmased metabollsm of primarily connective tissue cells. In a …

The 5′ flanking DNA of the rat insulin I gene contains sequences controlling cell-specific
expression. Analysis of this region by replacement of specific portions with …