The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen
species (ROS). An adequate balance between ROS levels and antioxidant defenses is …

Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …

Human tyrosinase (hs TYR) is the key enzyme ensuring the conversion of l-tyrosine to
dopaquinone, thereby initiating melanin synthesis, ie, melanogenesis. Although the protein …

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

Flavonoids are becoming popular nutraceuticals. Different flavonoids show similar or distinct
biological effects on different tissues or cell types, which may limit or define their usefulness …

Background The cereal weevil, Sitophilus zeamais is one of the most destructive pests of
stored cereals worldwide. Frequent use of fumigants for managing stored-product insects …

The DNA-encoded library (DEL) is a powerful hit-generation tool in drug discovery. This
study describes a new DEL with a privileged scaffold quinazolin-4 (3 H)-one developed by a …

Altered redox metabolism is one of the hallmarks of tumor cells, which not only contributes to
tumor proliferation, metastasis, and immune evasion, but also has great relevance to …