The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Transposable elements (TEs) are major contributors of genetic material in mammalian
genomes. These often include binding sites for architectural proteins, including the …

The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

Differences in three-dimensional (3D) chromatin architecture can influence the integrity of
topologically associating domains (TADs) and rewire specific enhancer–promoter …

BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal
melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex …

Chromatin compartmentalization reflects biological activity. However, inference of chromatin
sub-compartments and compartment domains from chromosome conformation capture (Hi …

Background Polyploidy is ubiquitous in eukaryotic plant and fungal lineages, and it leads to
the co-existence of several copies of similar or related genomes in one nucleus. In plants …

Prostate cancer is the most common non-cutaneous cancer and the second leading cause
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …