Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity
owing to incorrect folding of the target protein or poor presentation to the immune system …

Vaccines against viral disease have traditionally relied on attenuated virus strains or
inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in …

Mature, infectious HIV‐1 particles contain a characteristic cone‐shaped core that encases
the viral RNA and replication proteins. The architectures of mature virions and isolated cores …

Baculoviruses are lethal pathogens of insects, predominantly of the order Lepidoptera.
These viruses have a biphasic life cycle, which greatly facilitates their use for …

The retroviral structural protein, Gag, is capable of independently assembling into virus-like
particles (VLPs) in living cells and in vitro. Immature VLPs of human immunodeficiency virus …

Vaccines against viral disease have traditionally relied on attenuated virus strains or
inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in …

Introduction: Over the past two decades, virus-like particles (VLPs) have been developed as
a new generation of vaccines against viral infections. Based on VLPs, chimeric VLPs (chi …

Designed genetic reconstruction of natural proteins started in the early 1980s when Alan R.
Fersht and his colleagues conceived the basic idea of protein engineering, ie, a mutational …

In retroviruses, the late (L) domain has been defined as a conserved motif in the Gag
polyprotein precursor that, when mutated, leads to the emergence of virus particles that fail …

Assembly of retrovirus-like particles only requires the expression of the Gag polyprotein
precursor. We have exploited this in the development of a model system for studying the …