Class II terpene cyclases: structures, mechanisms, and engineering

X Pan, JD Rudolf, LB Dong - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Assembly-line catalysis in bifunctional terpene synthases

JL Faylo, TA Ronnebaum… - Accounts of chemical …, 2021 - ACS Publications
Conspectus The magnificent chemodiversity of more than 95 000 terpenoid natural products
identified to date largely originates from catalysis by two types of terpene synthases …

Discovery of non-squalene triterpenes

H Tao, L Lauterbach, G Bian, R Chen, A Hou, T Mori… - Nature, 2022 - nature.com
All known triterpenes are generated by triterpene synthases (TrTSs) from squalene or
oxidosqualene. This approach is fundamentally different from the biosynthesis of short-chain …

Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis

R Chen, Q Jia, X Mu, B Hu, X Sun… - Proceedings of the …, 2021 - National Acad Sciences
Chimeric terpene synthases, which consist of C-terminal prenyltransferase (PT) and N-
terminal class I terpene synthase (TS) domains (termed PTTSs here), is unique to fungi and …

Sesterterpenoids: chemistry, biology, and biosynthesis

K Li, KR Gustafson - Natural Product Reports, 2021 - pubs.rsc.org
Covering: July 2012 to December 2019 Over the last seven years, expanding research
efforts focused on sesterterpenoids has led to the isolation, identification, and …

Structural insight on assembly-line catalysis in terpene biosynthesis

JL Faylo, T van Eeuwen, HJ Kim… - Nature …, 2021 - nature.com
Fusicoccadiene synthase from Phomopsis amygdali (PaFS) is a unique bifunctional
terpenoid synthase that catalyzes the first two steps in the biosynthesis of the diterpene …

Overview of fungal terpene synthases and their regulation

RA González-Hernández, NA Valdez-Cruz… - World Journal of …, 2023 - Springer
Terpenes and terpenoids are a group of isoprene-derived molecules that constitute the
largest group of natural products and secondary metabolites produced by living things, with …

Exploring the influence of domain architecture on the catalytic function of diterpene synthases

TA Pemberton, M Chen, GG Harris, WKW Chou… - Biochemistry, 2017 - ACS Publications
Terpenoid synthases catalyze isoprenoid cyclization reactions underlying the generation of
more than 80,000 natural products. Such dramatic chemodiversity belies the fact that these …

Chimeric terpene synthases possessing both terpene cyclization and prenyltransfer activities

T Mitsuhashi, I Abe - ChemBioChem, 2018 - Wiley Online Library
Prenyltransferase (PT) and terpene synthase (TPS) are key enzymes in the formation of the
basic carbon skeletons of terpenoids. The PTs determine the prenyl carbon chain length …

Identification and characterization of bifunctional drimenol synthases of marine bacterial origin

NNQ Vo, Y Nomura, K Kinugasa, H Takagi… - ACS Chemical …, 2022 - ACS Publications
Natural drimane-type sesquiterpenes, including drimenol, display diverse biological
activities. These active compounds are distributed in plants and fungi; however, their …