One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …

Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

Despite the physiological complexity of the hypothalamus, its role is typically restricted to
initiation or cessation of innate behaviors. For example, theories of lateral hypothalamus …

Complex motivated behavioral processes, such as those that can go awry following
substance abuse and other neuropsychiatric disorders, are mediated by a distributive …

In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays
an important role in drug addiction. However, neural circuits underlying LH involvement of …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …

The tight regulation of sleep/wake states is critical for mental and physiological wellbeing.
For example, dysregulation of sleep/wake systems predisposes individuals to metabolic …