Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
Gene–environment correlations across geographic regions affect genome-wide association studies
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
Resource profile and user guide of the Polygenic Index Repository
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …
[PDF][PDF] 15 years of GWAS discovery: Realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Dissecting polygenic signals from genome-wide association studies on human behaviour
A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …
of polygenic signals with significant predictive power and potentially useful biological clues …
Discovery and implications of polygenicity of common diseases
The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …
common diseases: the number of genomic variants that contribute to risk of disease and …
Mendelian imputation of parental genotypes improves estimates of direct genetic effects
Abstract Effects estimated by genome-wide association studies (GWASs) include effects of
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing)
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …