Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review

J Lu, K Karkouti, M Peer, M Englesakis… - Canadian Journal of …, 2023 - Springer
Purpose Cold-stored platelets (CSP) are an increasingly active topic of international
research. They are maintained at 1–6° C, in contrast to standard room-temperature platelets …

The missing pieces to the cold-stored platelet puzzle

H Zhao, DV Devine - International Journal of Molecular Sciences, 2022 - mdpi.com
Cold-stored platelets are making a comeback. They were abandoned in the late 1960s in
favor of room-temperature stored platelets due to the need for longer post-transfusion …

Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen

Y Ma, J Zhang, Y Tian, Y Fu, S Tian, Q Li… - Nature …, 2023 - nature.com
The immediate processing of whole blood specimen is required in circulating tumor cell-
based liquid biopsy. Reliable blood specimen stabilization towards preserving circulating …

Low titer group O whole blood utilization in pediatric trauma resuscitation: a national survey

D Meshkin, MH Yazer, NM Dunbar, PC Spinella… - …, 2022 - Wiley Online Library
Background Renewed interest in low titer group O whole blood (LTOWB) transfusion has led
to increased utilization in adult trauma centers; little is known regarding LTOWB use in …

Refrigeration of apheresis platelets in platelet additive solution (PAS‐E) supports in vitro platelet quality to maximize the shelf‐life

L Johnson, S Vekariya, B Wood, S Tan, C Roan… - …, 2021 - Wiley Online Library
Background Refrigeration, or cold‐storage, of platelets may be beneficial to extend the
limited shelf‐life of conventionally stored platelets and support transfusion protocols in rural …

Cold‐stored platelets have better preserved contractile function in comparison with room temperature‐stored platelets over 21 days

PM Nair, MA Meledeo, AR Wells, X Wu, JA Bynum… - …, 2021 - Wiley Online Library
Although it is well established that transfusion of platelets in cases of severe bleeding
reduces mortality, the availability of platelets is hampered by harsh restrictions on shelf life …

The role of sodium citrate during extended cold storage of platelets in platelet additive solutions

L Johnson, C Roan, P Lei, PC Spinella… - Transfusion, 2023 - Wiley Online Library
Background Cold‐stored platelets are increasingly being used to treat bleeding. Differences
in manufacturing processes and storage solutions can affect platelet quality and may …

Short-term assays for mesenchymal stromal cell immunosuppression of T-lymphocytes

MC Herzig, BA Christy, RK Montgomery… - Frontiers in …, 2023 - frontiersin.org
Introduction Trauma patients are susceptible to coagulopathy and dysfunctional immune
responses. Mesenchymal stromal cells (MSCs) are at the forefront of the cellular therapy …

In vitro quality of cold and delayed cold‐stored platelet concentrates from interim platelet units during storage for 21 days

H Braathen, TH Felli Lunde, J Assmus… - Vox …, 2023 - Wiley Online Library
Abstract Background and Objectives Based on previous success using apheresis platelets,
we wanted to investigate the in vitro quality and platelet function in continuously cold‐stored …

Platelet dysfunction reversal with cold-stored vs room temperature–stored platelet transfusions

VJ Kogler, JA Miles, T Özpolat, SL Bailey, DA Byrne… - Blood, 2024 - ashpublications.org
Platelets are stored at room temperature for 5 to 7 days (room temperature–stored platelets
[RSPs]). Because of frequent and severe shortages, the US Food and Drug Administration …