The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker

DA Muller, PR Young - Antiviral research, 2013 - Elsevier
The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and
mechanistic function have remained somewhat elusive ever since it was first reported in …

West Nile encephalitis: an emerging disease in the United States

LJ Strausbaugh, AA Marfin… - Clinical infectious …, 2001 - academic.oup.com
In 1999, an epidemic of West Nile virus (WNV) encephalitis occurred in New York City (NYC)
and 2 surrounding New York counties. Simultaneously, an epizootic among American crows …

Antigen‐specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis

WE Purtha, N Myers, V Mitaksov, E Sitati… - European journal of …, 2007 - Wiley Online Library
Abstract Infection with West Nile virus (WNV) causes fatal encephalitis in
immunocompromised animals. Previous studies in mice have established that T cell …

Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells

VD Krishna, M Rangappa… - Journal of virology, 2009 - Am Soc Microbiol
We demonstrate the presence of nonstructural protein 1 (NS1)-specific antibodies in a
significant proportion of convalescent-phase human serum samples obtained from a cohort …

Protective Mechanisms Induced by a Japanese Encephalitis Virus DNA Vaccine: Requirement for Antibody but Not CD8+Cytotoxic T-Cell Responses

CH Pan, HW Chen, HW Huang, MH Tao - Journal of Virology, 2001 - Am Soc Microbiol
We have previously shown that a plasmid (pE) encoding the Japanese encephalitis virus
(JEV) envelope (E) protein conferred a high level of protection against a lethal viral …

Protective immunity to Japanese encephalitis virus associated with anti-NS1 antibodies in a mouse model

Y Li, D Counor, P Lu, V Duong, Y Yu, V Deubel - Virology journal, 2012 - Springer
Background Japanese encephalitis virus (JEV) is a major mosquito-borne pathogen that
causes viral encephalitis throughout Asia. Vaccination with an inactive JEV particle or …

Immune mediated and inherited defences against flaviviruses

MA Brinton, I Kurane, A Mathew, L Zeng, PY Shi… - Clinical and diagnostic …, 1998 - Elsevier
Background: Flavivirus infection elicits an abundant immune response in the host which is
directed against a number of the viral proteins. Resistance to flavivirus-induced disease can …

A synthetic peptide based on the NS1 non-structural protein of tick-borne encephalitis virus induces a protective immune response against fatal encephalitis in an …

OM Volpina, TD Volkova, DO Koroev, VT Ivanov… - Virus research, 2005 - Elsevier
Linear immunogenic peptides corresponding to amino acid sequences from the NS1 non-
structural protein from tick-borne encephalitis virus (strain Sophyin) were predicted using …

Immunobiology of Japanese encephalitis virus

M Larena, M Lobigs - Flavivirus Encephalitis, 2011 - books.google.com
Japanese encephalitis (JE) is an acute central nervous system inflammatory disease cause
by infection with Japanese encephalitis virus (JEV), a small, enveloped, plus-strand RNA …

Primary and Secondary Immune Responses During Sequential West Nile Virus and Japanese Encephalitis Virus Infections: A Dissertation

DW Trobaugh - 2012 - repository.escholarship.umassmed …
Japanese encephalitis virus (JEV) and West Nile virus (WNV) are closely related
Flaviviruses that are important arthropod-borne human pathogens. Both of these viruses can …