Electron micrographs first confirmed that the eukaryotic genome is organized into repeating
disk-shaped nucleosomal units composed of histones and their associated DNA. Those …

Thirty years ago, our conception of chromatin structure underwent a total metamorphosis as
the nucleosome era began. In Kurosawa's classic movie'Rashomon'(1951), each participant …

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2
diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer …

Solvent binding in the nucleosome core particle containing a 147 base pair, defined-
sequence DNA is characterized from the X-ray crystal structure at 1.9 Å resolution. A single …

The chromodomain of the HP1 family of proteins recognizes histone tails with specifically
methylated lysines. Here, we present structural, energetic, and mutational analyses of the …

Revealing the energy landscape for nucleosome association may contribute to the
understanding of higher-order chromatin structures and their impact on genome regulation …

Intrinsically disordered proteins and regions carry out varied and vital cellular functions.
Proteins with disordered regions are especially common in eukaryotic cells, with a subset of …

Chromatin is composed of nucleosomes, the universally repeating protein—DNA complex in
eukaryotic cells. The crystal structure of the nucleosome core particle from Saccharomyces …

Chromatin structure plays an important role in modulating the accessibility of genomic DNA
to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of …

Genetic studies have identified residues in the structured regions of the histones that are
critically involved in the formation of heterochromatin. Any investigation of the events that …