Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …

Background MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA
targets. In addition, mammalian genomes contain numerous natural antisense transcripts …

MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene
regulation in a sequence-specific manner. However, little is understood about the role (s) of …

Elevated levels of β-site APP cleaving enzyme 1 (BACE1) were found in the brain of some
sporadic Alzheimer's disease (AD) patients; however, the underlying mechanism is …

The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the
pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 …

The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic
Alzheimer's disease (AD) is unknown. A history of stroke was found to be associated with …