Endosome maturation
J Huotari, A Helenius - The EMBO journal, 2011 - embopress.org
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Lysosomal size matters
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …
signaling and quality control functions. Lysosomes are not static and they respond …
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P
Mutations that cause defects in levels of the signaling lipid phosphatidylinositol 3, 5-
bisphosphate [PI (3, 5) P2] lead to profound neurodegeneration in mice. Moreover …
bisphosphate [PI (3, 5) P2] lead to profound neurodegeneration in mice. Moreover …
Phosphatidylinositol 3, 5‐bisphosphate: low abundance, high significance
AJ McCartney, Y Zhang, LS Weisman - BioEssays, 2014 - Wiley Online Library
Recent studies of the low abundant signaling lipid, phosphatidylinositol 3, 5‐bisphosphate
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid …
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like
kinases) are implicated in the onset and development of Alzheimer's disease and Down …
kinases) are implicated in the onset and development of Alzheimer's disease and Down …
Lysosome fission: planning for an exit
GT Saffi, RJ Botelho - Trends in cell biology, 2019 - cell.com
Lysosomes are acidic and degradative organelles that receive and digest a plethora of
molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis …
molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis …
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve−/− embryos but normality of PIKfyve+/− mice
OC Ikonomov, D Sbrissa, K Delvecchio, Y Xie… - Journal of Biological …, 2011 - ASBMB
Gene mutations in the phosphoinositide-metabolizing enzymes are linked to various human
diseases. In mammals, PIKfyve synthesizes PtdIns (3, 5) P 2 and PtdIns5P lipids that …
diseases. In mammals, PIKfyve synthesizes PtdIns (3, 5) P 2 and PtdIns5P lipids that …
Phosphoinositides and vesicular membrane traffic
P Mayinger - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Phosphoinositide lipids were initially discovered as precursors for specific second
messengers involved in signal transduction, but have now taken the center stage in …
messengers involved in signal transduction, but have now taken the center stage in …
Phosphatidylinositol‐3,5‐Bisphosphate: No Longer the Poor PIP2
CY Ho, TA Alghamdi, RJ Botelho - Traffic, 2012 - Wiley Online Library
Phosphoinositides play an important role in organelle identity by recruiting effector proteins
to the host membrane organelle, thus decorating that organelle with molecular identity …
to the host membrane organelle, thus decorating that organelle with molecular identity …