Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease caused by
deficient activity of acid sphingomyelinase (ASM) enzyme, leading to the accumulation of …

Background The investigation of lncRNAs has provided a novel perspective for elucidating
mechanisms underlying diverse physiological and pathological processes. Compelling …

Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms,
making them both a fascinating host cell, in general, and an intriguing choice for the deadly …

The long external filament of bacterial flagella is composed of several thousand copies of a
single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in …

Shigella sonnei is a gram-negative bacterium and is the primary cause of shigellosis in
advanced countries. An exceptional rise in the prevalence of the disease has been reported …

The sharp increase in infections associated with multidrug-resistant (MDR) bacterial
pathogens that have seriously compromised traditional chemotherapeutics is becoming a …

The study of metabolic changes associated with host–pathogen interactions have largely
focused on the strategies that microbes use to subvert host metabolism to support their own …

MicroRNAs (miRNAs) are increasingly recognized for their role in infection by bacterial
pathogens, although the effect of each individual miRNA remains largely unknown. Here, we …

Breakdown of the inert and constitutive membrane building block sphingomyelin to the
highly active lipid mediator ceramide by extracellularly active acid sphingomyelinase is …

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is a major cause of
foodborne gastrointestinal illness. The adhesion of EHEC to host tissues is the first step …