Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

Many studies have suggested a role for gut-resident microbes (the" gut microbiome") in
modulating host health; however, the mechanisms by which they impact systemic physiology …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation
where BAs exert their multiple physiological functions including stimulation of bile flow …

Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid
homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease …