Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

[HTML][HTML] Lipid nanoparticles as carriers for bioactive delivery

N Dhiman, R Awasthi, B Sharma, H Kharkwal… - Frontiers in …, 2021 - frontiersin.org
Nanotechnology has made a great impact on the pharmaceutical, biotechnology, food, and
cosmetics industries. More than 40% of the approved drugs are lipophilic and have poor …

Nanocarriers-mediated drug delivery systems for anticancer agents: an overview and perspectives

Z Edis, J Wang, MK Waqas, M Ijaz… - International journal of …, 2021 - Taylor & Francis
Nanotechnology has been actively integrated as drug carriers over the last few years to treat
various cancers. The main hurdle in the clinical management of cancer is the development …

[HTML][HTML] Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

CP Costa, JN Moreira, JMS Lobo, AC Silva - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The management of the central nervous system (CNS) disorders is challenging, due to the
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …

Curcumin nanoformulations: Beneficial nanomedicine against cancer

S Maleki Dizaj, M Alipour… - Phytotherapy …, 2022 - Wiley Online Library
Curcumin is a phytochemical achieved from the plant turmeric. It is extensively utilized for
the treatment of several types of diseases such as cancers. Nevertheless, its efficiency has …

[HTML][HTML] A review on polymer and lipid-based nanocarriers and its application to nano-pharmaceutical and food-based systems

H Lu, S Zhang, J Wang, Q Chen - Frontiers in nutrition, 2021 - frontiersin.org
Recently, owing to well-controlled release, enhanced distribution and increased
permeability, nanocarriers used for alternative drug and food-delivery strategies have …

[HTML][HTML] Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances

S Jacob, AB Nair, J Shah, S Gupta, SHS Boddu… - Pharmaceutics, 2022 - mdpi.com
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …

[HTML][HTML] Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

K Mahmoud, S Swidan, M El-Nabarawi… - Journal of …, 2022 - Springer
Liver cancer is considered one of the deadliest diseases with one of the highest disease
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …

Solid lipid nanoparticles and nanostructured lipid carriers: A review of the methods of manufacture and routes of administration

J Akbari, M Saeedi, F Ahmadi… - Pharmaceutical …, 2022 - Taylor & Francis
The bioavailability of drugs is dependent on several factors such as solubility and the
administration route. A drug with poor aqueous solubility, therefore, poses challenges with …

[HTML][HTML] Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges

T Skotland, TG Iversen, A Llorente, K Sandvig - Advanced drug delivery …, 2022 - Elsevier
There is a large interest in developing nanoparticles and extracellular vesicles for delivery of
therapeutics or imaging agents. Regulatory approval of such products requires knowledge …