Skeletal editing: interconversion of arenes and heteroarenes

BW Joynson, LT Ball - Helvetica Chimica Acta, 2023 - Wiley Online Library
Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …

Dynamic crosslinking compatibilizes immiscible mixed plastics

RW Clarke, T Sandmeier, KA Franklin, D Reich… - Nature, 2023 - nature.com
The global plastics problem is a trifecta, greatly affecting environment, energy and climate,,–.
Many innovative closed/open-loop plastics recycling or upcycling strategies have been …

Photocrosslinkable natural polymers in tissue engineering

SH Moon, HJ Hwang, HR Jeon, SJ Park… - … in Bioengineering and …, 2023 - frontiersin.org
Natural polymers have been widely used in scaffolds for tissue engineering due to their
superior biocompatibility, biodegradability, and low cytotoxicity compared to synthetic …

Unified access to pyrimidines and quinazolines enabled by N–N cleaving carbon atom insertion

EE Hyland, PQ Kelly, AM McKillop… - Journal of the …, 2022 - ACS Publications
Given the ubiquity of heterocycles in biologically active molecules, transformations with the
capacity to modify such molecular skeletons with modularity remain highly desirable. Ring …

Covalent bonding strategy to enable non-volatile organic cation perovskite for highly stable and efficient solar cells

K Liu, S Rafique, SF Musolino, Z Cai, F Liu, X Li… - Joule, 2023 - cell.com
The loss of organic components from perovskites has inevitably triggered a series of
undesirable results, including ion migration, increased defects, and organic vapors, which …

Photochemically mediated ring expansion of indoles and pyrroles with chlorodiazirines: synthetic methodology and thermal hazard assessment

BW Joynson, GR Cumming… - Angewandte Chemie …, 2023 - Wiley Online Library
We demonstrate that arylchlorodiazirines serve as photo‐activated halocarbene precursors
for the selective one‐carbon ring expansion of N‐substituted pyrroles and indoles to the …

Beyond a linker: the role of photochemistry of crosslinkers in the direct optical patterning of colloidal nanocrystals

S Lu, Z Fu, F Li, K Weng, L Zhou… - Angewandte Chemie …, 2022 - Wiley Online Library
Surface chemistry mediated direct optical patterning represents an emerging strategy for
incorporating colloidal nanocrystals (NCs) in integrated optoelectronic platforms including …

Biocatalytic carbene transfer using diazirines

NJ Porter, E Danelius, T Gonen… - Journal of the American …, 2022 - ACS Publications
Biocatalytic carbene transfer from diazo compounds is a versatile strategy in asymmetric
synthesis. However, the limited pool of stable diazo compounds constrains the variety of …

Photocatalytic Activation of Aryl (trifluoromethyl) Diazos to Carbenes for High-Resolution Protein Labeling with Red Light

DC Cabanero, SK Kariofillis, AC Johns… - Journal of the …, 2024 - ACS Publications
State-of-the-art methods in photoproximity labeling center on the targeted generation and
capture of short-lived reactive intermediates to provide a snapshot of local protein …

Dissecting diazirine photo-reaction mechanism for protein residue-specific cross-linking and distance mapping

Y Jiang, X Zhang, H Nie, J Fan, S Di, H Fu… - Nature …, 2024 - nature.com
While photo-cross-linking (PXL) with alkyl diazirines can provide stringent distance restraints
and offer insights into protein structures, unambiguous identification of cross-linked residues …