Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Physical properties of nanoparticles that result in improved cancer targeting

R Zein, W Sharrouf, K Selting - Journal of Oncology, 2020 - Wiley Online Library
The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target,
and drug penetration into tumors is limited by abnormal vasculature and high interstitial …

Smart transformable nanoparticles for enhanced tumor theranostics

J Chen, Z Jiang, YS Zhang, J Ding, X Chen - Applied Physics Reviews, 2021 - pubs.aip.org
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …

A detailed insight of the tumor targeting using nanocarrier drug delivery system

S Batool, S Sohail, F ud Din, AH Alamri… - Drug Delivery, 2023 - Taylor & Francis
Human struggle against the deadly disease conditions is continued since ages. The
contribution of science and technology in fighting against these diseases cannot be ignored …

The importance of nanoparticle shape in cancer drug delivery

NP Truong, MR Whittaker, CW Mak… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Nanoparticles have been successfully used for cancer drug delivery since
1995. In the design of commercial nanoparticles, size and surface characteristics have been …

Design of virus-based nanomaterials for medicine, biotechnology, and energy

AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …

Effect of micro-and nanoparticle shape on biological processes

H Hadji, K Bouchemal - Journal of Controlled Release, 2022 - Elsevier
In the drug delivery field, there is beyond doubt that the shape of micro-and nanoparticles
(M&NPs) critically affects their biological fate. Herein, following an introduction describing …

Scalable and uniform length-tunable biodegradable block copolymer nanofibers with a polycarbonate core via living polymerization-induced crystallization-driven self …

CE Ellis, JD Garcia-Hernandez… - Journal of the American …, 2022 - ACS Publications
Uniform 1D block copolymer (BCP) nanofibers prepared by the seeded-growth approach
termed living crystallization-driven self-assembly (CDSA) offer promising potential for …

Shape transformable strategies for drug delivery

W Jia, Y Wang, R Liu, X Yu… - Advanced Functional …, 2021 - Wiley Online Library
In tumor therapy, nanodrug delivery systems have gained momentum in the last decade.
However, its efficacy remains insufficient for clinical applications. The physical properties of …

Immunological basis for enhanced immunity of nanoparticle vaccines

HG Kelly, SJ Kent, AK Wheatley - Expert Review of Vaccines, 2019 - Taylor & Francis
Introduction: Immunization has been a remarkably successful public health intervention;
however, new approaches to vaccine design are essential to counter existing and emerging …