Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

The challenges in the diagnosis, prognosis, and monitoring of Gaucher disease (GD), an
autosomal recessive inborn error of glycosphingolipid metabolism, can negatively impact …

Gaucher disease, the most prevalent lysosomal storage disease, is caused by homozygous
mutations at the GBA gene, which is responsible for encoding the enzyme …

Macrophages are key multi-talented cells of the innate immune system and are equipped
with receptors involved in damage and pathogen recognition with connected immune …

Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum
metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose …

While terrestrial organisms are the primary source of natural products, recent years have
witnessed a considerable shift towards marine-sourced biocompounds. They have achieved …

Background Molecules related to glucocerebrosidase (GCase) are potential biomarkers for
development of compounds targeting GBA1‐associated Parkinson's disease (GBA‐PD) …

Several guidelines are available for identification and management of patients with Gaucher
disease, but the most recent guideline was published in 2013. Since then, there have been …