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Human immunodeficiency virus type 1 (HIV-1) tropism can be assessed using phenotypic
assays, but this is quite laborious, expensive, and time-consuming and can be made only in …

Objective: Replacing phenotypic assays with simple genotypic predictions of HIV-1
coreceptor usage would make the clinical use of CCR5 antagonists easier. Design: Paired …

The evolution of human immunodeficiency virus type 1 (HIV-1) with respect to co-receptor
utilization has been shown to be relevant to HIV-1 pathogenesis and disease. The CCR5 …

Objective: Cysteine-cysteine receptor 5 (CCR5)-using viruses classically predominate
during HIV-1 primary infection but the frequency of cysteine-X-cysteine receptor 4 (CXCR4) …

CCR5 antagonists have recently entered the HIV armamentarium. This novel class of drugs
inhibit viral entry blocking host cellular receptors, and therefore display unique mechanisms …

Objectives Evaluation of the reliability of several V3-based genotypic predictors to infer viral
tropism in patients infected with B and non-B strains of HIV-1. Methods Several genotypic …

Background: Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-
1 infection than in subtype B for reasons that are unclear. We have examined sequential …

Objective The aim of the study was to evaluate the use of proviral DNA as a source of viral
genetic material for genotypic coreceptor tropism testing (GTT). Methods GTT consisted of …

Background Genotypic tools may allow easier and less expensive estimation of HIV tropism
before prescription of CCR5 antagonists compared with the Trofile® assay (Monogram …