Lithium and hormesis: Enhancement of adaptive responses and biological performance via hormetic mechanisms

EJ Calabrese, P Pressman, AW Hayes… - Journal of Trace …, 2023 - Elsevier
Biomedical and consumer interest in the health-promoting properties of pure single entities
of known or unknown chemical constituents and mixtures has never been greater. Since its …

Lithium: a promising anticancer agent

EY Villegas-Vázquez, LI Quintas-Granados, H Cortés… - Life, 2023 - mdpi.com
Lithium is a therapeutic cation used to treat bipolar disorders but also has some important
features as an anti-cancer agent. In this review, we provide a general overview of lithium …

[HTML][HTML] Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway

R Yao, X Sun, Y Xie, L Liu, D Han, Y Yao… - American journal of …, 2018 - ncbi.nlm.nih.gov
Multiple myeloma (MM) is an extremely malignant plasma cell disease, which is still
incurable due to its drug resistance. Lithium chloride (LiCl) functions in many pathological …

Six2 promotes non–small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E‐cadherin

H Hou, X Yu, P Cong, Y Zhou, Y Xu, Y Jiang - Cell Proliferation, 2019 - Wiley Online Library
Objectives The roles and related mechanisms of six2 in regulating non–small cell lung
cancer (NSCLC) cells progression are unclear. This work aimed to explore the roles of six2 …

The Wnt/β-catenin/Lef1 pathway promotes cell proliferation at least in part through direct upregulation of miR-17-92 cluster

F Mu, J Huang, T Xing, Y Jing, T Cui, Y Guo… - Frontiers in …, 2019 - frontiersin.org
The miR-17-92 cluster is involved in animal development and homeostasis, and its
dysregulation leads to human diseases such as cancer. In the present study, we …

Overexpression of aquaporin 1 in synovium aggravates rat collagen-induced arthritis through regulating β-Catenin signaling: an in vivo and in vitro study

Y Mu, M Zhou, L Cai, M Liu, R Li - Journal of Inflammation …, 2020 - Taylor & Francis
Introduction Previous studies have confirmed that aquaporin 1 (AQP1) is up-regulated in
synovium of rheumatoid arthritis (RA), but its exact pathogenic mechanisms in RA are …

Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex

WC Hsieh, S Ramadesikan, D Fekete, RC Aguilar - PLoS One, 2018 - journals.plos.org
Lowe syndrome is an X-linked condition characterized by congenital cataracts, neurological
abnormalities and kidney malfunction. This lethal disease is caused by mutations in the …

[HTML][HTML] Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells

JW Li, CZ Huang, JH Li, JH Yuan, QH Chen… - Biomedicine & …, 2018 - Elsevier
This work aims to study the roles and related mechanisms of six2 in 5-FU sensitivity of
hepatocellular carcinoma (HCC) cells. KM-Plotter analysis showed that HCC patients with …

Lithium's renaissance: From psychiatric staple to multifaceted medical marvel

JR Ravan, JI Pattnaik, UK Panda… - Journal of Integrative …, 2024 - journals.lww.com
Lithium, long established as a cornerstone in the treatment of bipolar disorder, has recently
emerged as a potential therapeutic agent across a broad spectrum of medical fields. This …