Neurocognitive effects of antiseizure medications in children and adolescents with epilepsy

FMC Besag, MJ Vasey - Pediatric Drugs, 2021 - Springer
Impairments in cognition are common in epilepsy and may be caused or exacerbated by
antiseizure medications (ASMs). Positive effects on cognition may also be seen with some …

Efficacy and safety of levetiracetam vs. phenobarbital for neonatal seizures: a systematic review and meta-analysis

MY Qiao, HT Cui, LZ Zhao, JK Miao… - Frontiers in Neurology, 2021 - frontiersin.org
Background: Neonatal seizures are a common neurological emergency in newborns.
Phenobarbital (PB) is the first-line antiepileptic drug (AED). However, PB has some side …

Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial

C Sharpe, GE Reiner, SL Davis, M Nespeca… - …, 2020 - publications.aap.org
METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Treatment of neonatal seizures: comparison of treatment pathways from 11 neonatal intensive care units

JC Keene, LA Morgan, NS Abend, SV Bates… - Pediatric …, 2022 - Elsevier
Objective Seizures are a common neonatal neurologic emergency. Many centers have
developed pathways to optimize management. We evaluated neonatal seizure management …

A systematic review of the efficacy of levetiracetam in neonatal seizures

DC McHugh, S Lancaster, LN Manganas - Neuropediatrics, 2018 - thieme-connect.com
Objective Seizures are the most common neurological complication in neonatal intensive
care units. Phenobarbital (PB) remains the first-line antiepileptic drug (AED) for neonatal …

Perinatal brain injury and inflammation: lessons from experimental murine models

A Leavy, EM Jimenez Mateos - Cells, 2020 - mdpi.com
Perinatal brain injury or neonatal encephalopathy (NE) is a state of disturbed neurological
function in neonates, caused by a number of different aetiologies. The most prominent cause …

Levetiracetam in neonatal seizures: a review

AL Mruk, KL Garlitz, NR Leung - The Journal of Pediatric …, 2015 - meridian.allenpress.com
Phenobarbital and phenytoin have been the mainstay treatment modalities for neonatal
seizures. Studies have revealed these agents control seizures in less than half of neonates …

Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats

I Sanchez-Brualla, A Ghosh, VA Gibatova… - Frontiers in …, 2023 - frontiersin.org
Introduction Neonatal hypoxia is a common cause of early-life seizures. Both hypoxia-
induced seizures (HS), and the drugs used to treat them (eg, phenobarbital, PB), have been …

Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014

KA Ahmad, SJ Desai, MM Bennett, SF Ahmad… - Journal of …, 2017 - nature.com
Objective: Neonatal seizures are a common problem in the neonatal intensive care unit and
are frequently treated with antiepileptic drugs. Limited data exist on current or changing …

[HTML][HTML] Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center …

C Basti, E Maranella, N Cimini, A Catalucci, S Ciccarelli… - Seizure, 2020 - Elsevier
Objective To examine the relationship between electrographic seizures and developmental
outcome at 18 and 24 months in neonates with moderate and severe hypoxic-ischemic …