New approaches to understanding p53 gene tumor mutation spectra
M Hollstein, M Hergenhahn, Q Yang, H Bartsch… - Mutation Research …, 1999 - Elsevier
The first p53 gene mutation arising in a human tumor was described a decade ago by Baker
et al.[SJ Baker, ER Fearon, JM Nigro, SR Hamilton, AC Preisinger, JM Jessup, P. van …
et al.[SJ Baker, ER Fearon, JM Nigro, SR Hamilton, AC Preisinger, JM Jessup, P. van …
Mutation detection by denaturing gradient gel electrophoresis (DGGE)
R Fodde, M Losekoot - Human mutation, 1994 - Wiley Online Library
The molecular analysis of genetic diseases relies on several technical approaches which
allow genetic and physical mapping, characterization of the gene structure, expression …
allow genetic and physical mapping, characterization of the gene structure, expression …
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
A Kat, WG Thilly, WH Fang… - Proceedings of the …, 1993 - National Acad Sciences
The human lymphoblastoid MT1 B-cell line was previously isolated as one of a series of
mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine …
mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine …
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
P Keohavong, MA DeMichele, AC Melacrinos… - Clinical cancer research …, 1996 - AACR
The K-ras mutation is one of the most common genetic alterations found in human lung
cancer. To evaluate the prognostic value of ras gene alterations in lung cancer in a US …
cancer. To evaluate the prognostic value of ras gene alterations in lung cancer in a US …
Translesion Synthesis by Human DNA Polymerase κ on a DNA Template Containing a Single Stereoisomer of dG-(+)- or dG-(−)-anti-N2-BPDE (7,8-Dihydroxy-anti-9,10-epoxy …
N Suzuki, E Ohashi, A Kolbanovskiy, NE Geacintov… - Biochemistry, 2002 - ACS Publications
Several recently discovered human DNA polymerases are associated with translesion
synthesis past DNA adducts. These include human DNA polymerase κ (pol κ), a homologue …
synthesis past DNA adducts. These include human DNA polymerase κ (pol κ), a homologue …
Genotypic selection methods for the direct analysis of point mutations
BL Parsons, RH Heflich - Mutation Research/Reviews in Mutation …, 1997 - Elsevier
Genotypic selection enriches a particular DNA sequence relative to another closely-related
DNA sequence based only on a change of one or a few bases. This review is a survey of the …
DNA sequence based only on a change of one or a few bases. This review is a survey of the …
Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells.
JC Willey, E Coy, C Brolly, MJ Utell… - American journal of …, 1996 - atsjournals.org
Human bronchial epithelial cells (BEC), a primary defense against inhaled materials, are the
progenitor cells for bronchogenic carcinomas and have important metabolic capabilities. We …
progenitor cells for bronchogenic carcinomas and have important metabolic capabilities. We …
Fidelity of Translesional Synthesis past Benzo[a]pyrene Diol Epoxide−2'-Deoxyguanosine DNA Adducts: Marked Effects of Host Cell, Sequence Context, and …
M Moriya, S Spiegel, A Fernandes, S Amin, T Liu… - Biochemistry, 1996 - ACS Publications
We have used a site-specific approach to investigate the mutagenic potential of (+)-and (−)-
trans-anti-benzo [a] pyrene diol epoxide (BPDE) DNA adducts. Oligodeoxyribonucleotides …
trans-anti-benzo [a] pyrene diol epoxide (BPDE) DNA adducts. Oligodeoxyribonucleotides …
Mutagenic Potential of Stereoisomeric Bay Region (+)- and (−)-cis-anti-Benzo[a]pyrene Diol Epoxide-N2-2'-deoxyguanosine Adducts in Escherichia coli and …
A Fernandes, T Liu, S Amin, NE Geacintov… - Biochemistry, 1998 - ACS Publications
We have investigated the mutagenic potential of site-specifically positioned DNA adducts
with (+)-and (−)-cis-anti stereochemistry derived from the binding of r 7, t 8-dihydroxy-t 9, 10 …
with (+)-and (−)-cis-anti stereochemistry derived from the binding of r 7, t 8-dihydroxy-t 9, 10 …
Interaction of the UvrABC nuclease system with a DNA duplex containing a single stereoisomer of dG-(+)-or dG-(-)-anti-BPDE
Revised Manuscript Received August 8, 1995® abstract: Oligonucleotides containing site-
specifically-modified A^-guanine (+)-trans-,(-)-trans-,(+)-cis-, and (—)-ds-BPDE adducts …
specifically-modified A^-guanine (+)-trans-,(-)-trans-,(+)-cis-, and (—)-ds-BPDE adducts …