With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin
resistance, despite performing daily intense physical exercise that would lead to muscle …

Alterations in the circadian system are characteristic of aging on Earth. With the decline in
physiological processes due to aging, several health concerns including vision loss …

Prolonged unloading of skeletal muscle, a common outcome of events such as spaceflight,
bed rest and hindlimb unloading, can result in extensive metabolic, structural and functional …

Widespread generation and analysis of omics data have revolutionized molecular medicine
on Earth, yet its power to yield new mechanistic insights and improve occupational health …

The molecular mechanisms of skeletal muscle adaptation to spaceflight are as yet not fully
investigated and well understood. The MUSCLE BIOPSY study analyzed pre and postflight …

Human spaceflight is associated with a substantial loss of skeletal muscle mass and muscle
strength. Neuromuscular electrical stimulation (NMES) evokes involuntary muscle …

The dissociation of bone formation and resorption is an important physiological process
during spaceflight. It also occurs during local skeletal unloading or immobilization, such as …

Precision oncology is an emerging approach in cancer care. It aims at selecting the optimal
therapy for the right patient by considering each patient's unique disease and individual …