Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
Neonatal T cells: a reinterpretation
BD Rudd - Annual review of immunology, 2020 - annualreviews.org
Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …
Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes
It has long been thought that clonal deletion efficiently removes almost all self-specific T
cells from the peripheral repertoire. We found that self-peptide MHC-specific CD8+ T cells in …
cells from the peripheral repertoire. We found that self-peptide MHC-specific CD8+ T cells in …
Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate
INTRODUCTION Successful immune responses to infections generate memory T cells that
provide enhanced protection from reinfection by the same pathogen. Some memory cells …
provide enhanced protection from reinfection by the same pathogen. Some memory cells …
Developmental origin governs CD8+ T cell fate decisions during infection
Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following
infection, naive T cells differentiate into various subsets of effector and memory T cells …
infection, naive T cells differentiate into various subsets of effector and memory T cells …
[HTML][HTML] Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
JT White, EW Cross, MA Burchill, T Danhorn… - Nature …, 2016 - nature.com
Virtual memory cells (VM) are an antigen-specific, memory phenotype CD8 T-cell subset
found in lymphoreplete, unchallenged mice. Previous studies indicated that VM cells were …
found in lymphoreplete, unchallenged mice. Previous studies indicated that VM cells were …
Memory CD4+ T cells are generated in the human fetal intestine
N Li, V van Unen, T Abdelaal, N Guo… - Nature …, 2019 - nature.com
The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO+ T cells
reside in the fetal intestine. Here we combined functional assays with mass cytometry, single …
reside in the fetal intestine. Here we combined functional assays with mass cytometry, single …
Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them
Memory-phenotype CD8+ T cells exist in substantial numbers within hosts that have not
been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced …
been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced …
T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors
AM Tsimberidou, K Van Morris, HH Vo, S Eck… - Journal of Hematology & …, 2021 - Springer
Abstract T-cell receptor (TCR)-based adoptive therapy employs genetically modified
lymphocytes that are directed against specific tumor markers. This therapeutic modality …
lymphocytes that are directed against specific tumor markers. This therapeutic modality …