Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …

Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

All multicellular organisms rely on differential gene transcription regulated by genomic
enhancers, which function through cofactors that are recruited by transcription factors …

Abstract ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …

Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …