Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes

Z Fu, E R. Gilbert, D Liu - Current diabetes reviews, 2013 - benthamdirect.com
Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

PVA Babu, D Liu, ER Gilbert - The Journal of nutritional biochemistry, 2013 - Elsevier
Flavonoids are polyphenolic compounds that are abundant in fruits and vegetables, and
increasing evidence demonstrates a positive relationship between consumption of flavonoid …

The biology of incretin hormones

DJ Drucker - Cell metabolism, 2006 - cell.com
Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

Mechanisms of action of glucagon-like peptide 1 in the pancreas

ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Oxidative stress and beta-cell dysfunction

G Drews, P Krippeit-Drews, M Düfer - Pflügers Archiv-European Journal of …, 2010 - Springer
Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?

F Bassil, PO Fernagut, E Bezard, WG Meissner - Progress in neurobiology, 2014 - Elsevier
Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function

L Shu, AV Matveyenko, J Kerr-Conte… - Human molecular …, 2009 - academic.oup.com
Recent human genetics studies have revealed that common variants of the TCF7L2 (T-cell
factor 7-like 2, formerly known as TCF4) gene are strongly associated with type 2 diabetes …

Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets

L Shu, NS Sauter, FT Schulthess, AV Matveyenko… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Type 2 diabetes is characterized by impaired insulin secretion in response to
increased metabolic demand. This defect in β-cell compensation seems to result from the …

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: involvement of 3′, 5′-cyclic adenosine …

R Granata, F Settanni, L Biancone, L Trovato… - …, 2007 - academic.oup.com
Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism.
Herein we investigated the role of ghrelin in pancreatic β-cell proliferation and apoptosis …

Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function

Y Zhang, D Liu - European journal of pharmacology, 2011 - Elsevier
Considerable evidence shows that chronic hyperglycemia can cause pancreatic beta-cell
dysfunction, which contributes to progressive deterioration of glucose homeostasis and overt …