Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Daily rhythms in behavior and physiology are programmed by a hierarchical collection of
biological clocks located throughout the brain and body, known as the circadian system …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Circadian rhythms control almost all aspects of physiology and behavior, allowing temporal
synchrony of these processes between each other, as well as with the external environment …

Objective Mortality in patients with primary adrenal insufficiency (PAI) is significantly
increased, with respiratory infections as a major cause of death. Moreover, patients with PAI …

Circadian clocks are a common feature of life on our planet, allowing physiology and
behaviour to be adapted to recurrent environmental fluctuation. There is now compelling …

Abnormalities in melatonin physiology may be involved or closely linked to the
pathophysiology and behavioral expression of autistic disorder, given its role in …

The importance of a neuroinflammatory response to the development and maintenance of
inflammatory and neuropathic pain have been highlighted in recent years. Inflammatory …

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …