Tuberculosis is the leading infectious disease responsible for an estimated one and a half
million human deaths each year around the globe. HIV-TB coinfection and rapid increase in …

Eighty years after the introduction of the first antituberculosis (TB) drug, the treatment of drug-
susceptible TB remains very cumbersome, requiring the use of four drugs (isoniazid …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …

Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

A new metabolomics database and query algorithm for the analysis of 13C–1H HSQC
spectra is introduced, which unifies NMR spectroscopic information on 555 metabolites from …

Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic
screening is of increasing importance. Metabolomics offers a potentially rapid and cost …

Highlights•Multidimensional NMR is a powerful tool for complex samples in metabolomics.•
Tailored 2D NMR strategies enable the accurate quantification of metabolites.•Fast 2D NMR …

Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of
biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) …

Flavonoids are organic compounds characterized by a range of phenolic structures, which
are abundantly present in various natural sources such as fruits, vegetables, cereals, bark …

Objectives d-Cycloserine is an important second-line drug used to treat MDR-and XDR-TB.
However, the mechanisms of resistance to d-cycloserine are not well understood. Here we …