During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Psoriasis is a common inflammatory skin disease characterized by the appearance of red
scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration …

Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved,
coordinating regulators of immune and inflammatory responses. They also play a pivotal …

There is increasing awareness that psoriasis is more than 'skin deep'. Several recent
reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the …

The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

Obesity is a major problem worldwide that increases risk for a wide range of diseases,
including diabetes and heart disease. As such, it is increasingly important to understand …

The past decade has seen an explosion in research focusing on innate immunity. Through a
wide range of mechanisms including phagocytosis, intracellular killing and activation of …

Type 2 diabetes mellitus is likely the third modifiable risk factor for pancreatic cancer after
cigarette smoking and obesity. Epidemiological investigations have found that long‐term …

The world is now experiencing an epidemic of obesity. Although the effects of obesity on the
development of metabolic and cardiovascular problems are well studied, much less is …