After receptor-mediated endocytosis, the intracellular fate of triglyceride-rich lipoproteins
(TRLs) is far more complex than the classical degradation pathway of low-density …

[Frontiers in Bioscience 6, d332-354, March 1, 2001] 332 POSTPRANDIAL LIPOPROTEINS
AND ATHEROSCLEROSIS Kenneth CW. Yu 1 and All Page 1 [Frontiers in Bioscience 6 …

Apolipoprotein E (apoE)-deficient mice develop marked hyperlipidemia as well as
atherosclerosis and thus are an excellent animal model for evaluating the potential for gene …

Smith JD, Breslow JL (Laboratory of Biochemical Genetics and Metabolism, The Rockefeller
University, New York, NY, USA). The emergence of mouse models of atherosclerosis and …

Transgenic technologies have provided a series of very useful mouse models to study
hyperlipidemia and atherosclerosis. Normally, mice carry cholesterol mainly in the high …

Apolipoprotein E (apoE) is a multifunctional protein synthesized by the liver and tissue
macrophages. ApoE-deficient mice have severe hyperlipidemia and develop accelerated …

Atherosclerosis, the underlying cause of coronary artery (CAD) and other cardiovascular
diseases, is initiated by macrophage-mediated immune responses to lipoprotein and …

Adenoviral vectors can direct high-level expression of a transgene, but, due to a host
immune response to adenoviral antigens, expression is of limited duration, and repetitive …

The apolipoprotein E (apoE)-deficient mouse is a relevant animal model of human
atherosclerosis. Although the prevention of atherosclerosis development has been …

Apolipoprotein E (apoE) plays a key role in lipoprotein metabolism and may have other
important biological functions. In humans, there are three common, naturally occurring …