Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Cysteine side chains can exist in distinct oxidation states depending on the pH and redox
potential of the environment, and cysteine oxidation plays important yet complex regulatory …

Conspectus Oxidative post-translational modifications (OxiPTMs) of cysteine residues are
the molecular foundation of thiol-based redox regulation that modulates physiological …

Protein analysis under biological conditions is now regarded as indispensable for
understanding the structure and function of proteins, in addition to in vitro studies using …

Click chemistry has been established rapidly as one of the most valuable methods for the
chemical transformation of complex molecules. Due to the rapid rates, clean conversions to …

Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) can inflict damage to
biomolecules under oxidative stress and also act as signaling molecules at physiological …

The mitochondrion is the primary energy generator of a cell and is a central player in cellular
redox regulation. Mitochondrial reactive oxygen species (mtROS) are the natural byproducts …

Sulfur-based functional groups are found in a broad range of natural products and
therapeutic compounds. The sulfoxide moiety is present in a significant portion of …

We report the late‐stage chemical modification of ribosomally synthesized and post‐
translationally modified peptides (RIPPs) by Diels–Alder cycloadditions to naturally …