Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

Gene-environment interactions drive experience-dependent changes in the brain that alter
cognition, emotion and behaviour. Positive engagement with the environment, through novel …

Huntington's disease (HD) is an extraordinary disorder that usually strikes when individuals
are in the prime of their lives, as was the case for the influential 20th century musician …

Environmental enrichment (EE) is a process of brain stimulation by modifying the
surroundings, for example, by changing the sensory, social, or physical conditions. Rodents …

Depression and apathy are associated with decreased functional capacity in Huntington's
disease (HD) but frequency of depression and apathy in HD is largely unknown. Systematic …

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …

Clinical evidence indicates that serotonin-1A receptor (5-HT 1A R) gene polymorphisms are
associated with anxiety disorders and deficits in cognition. In animal models, exercise (Ex) …

Along with being the main target of many antidepressant medications, the serotonin
transporter (5-HTT) is known to be involved in the pathophysiology of depression and …