AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …
Unlike many other neurodegenerative diseases with established gene–environment interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …
Gene-environment interactions drive experience-dependent changes in the brain that alter cognition, emotion and behaviour. Positive engagement with the environment, through novel …
Huntington's disease (HD) is an extraordinary disorder that usually strikes when individuals are in the prime of their lives, as was the case for the influential 20th century musician …
Environmental enrichment (EE) is a process of brain stimulation by modifying the surroundings, for example, by changing the sensory, social, or physical conditions. Rodents …
Depression and apathy are associated with decreased functional capacity in Huntington's disease (HD) but frequency of depression and apathy in HD is largely unknown. Systematic …
While Huntington disease (HD) is caused solely by a polyglutamine expansion in the huntingtin gene, environmental factors can influence HD onset and progression. Here, we …
J Rogers, U Vo, LS Buret, TY Pang… - Translational …, 2016 - nature.com
Clinical evidence indicates that serotonin-1A receptor (5-HT 1A R) gene polymorphisms are associated with anxiety disorders and deficits in cognition. In animal models, exercise (Ex) …
Along with being the main target of many antidepressant medications, the serotonin transporter (5-HTT) is known to be involved in the pathophysiology of depression and …