Neurological facets of scrub typhus: a comprehensive narrative review

D Garg, A Manesh - Annals of Indian Academy of Neurology, 2021 - journals.lww.com
Scrub typhus is one of the most frequent causes of acute febrile illness in South and South-
east Asian countries. Neurological features accompany 20% of scrub typhus infections, and …

[HTML][HTML] Orientia tsutsugamushi: The dangerous yet neglected foe from the East

A Banerjee, S Kulkarni - International Journal of Medical Microbiology, 2021 - Elsevier
Orientia tsutsugamushi (OT), the causative agent of the vector-borne Scrub typhus zoonotic
disease in humans, is a unique microorganism that exists in the Asia-Pacific region since a …

Scrub typhus in Northeast India: epidemiology, clinical presentations, and diagnostic approaches

BM Konyak, M Soni, S Saikia, T Chang… - Transactions of The …, 2024 - academic.oup.com
Scrub typhus is one of the most neglected tropical diseases, a leading cause of acute
undifferentiated febrile illness in areas of the 'tsutsugamushi triangle', diagnosed frequently …

Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in mice

Y Liang, Aditi, F Onyoni, H Wang, C Gonzales… - Frontiers in …, 2023 - frontiersin.org
Scrub typhus, an acute febrile illness caused by Orientia tsutsugamushi (Ot), is prevalent in
endemic areas with one million new cases annually. Clinical observations suggest central …

[HTML][HTML] Intranasal immunization with nanoparticles containing an Orientia tsutsugamushi protein vaccine candidate and a polysorbitol transporter adjuvant enhances …

CG Kim, WK Kim, N Kim, YJ Pyung, DJ Park… - Immune …, 2023 - ncbi.nlm.nih.gov
Scrub typhus, a mite-borne infectious disease, is caused by Orientia tsutsugamushi. Despite
many attempts to develop a protective strategy, an effective preventive vaccine has not been …

Efficacy and safety of antibiotics for treatment of scrub typhus: a network meta-analysis

J Yang, L Luo, T Chen, L Li, X Xu, Y Zhang… - JAMA Network …, 2020 - jamanetwork.com
Importance Antibiotics have been used for many years to treat scrub typhus, but their efficacy
and safety have not been studied thoroughly. Objective To compare and rank different …

Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

B Trent, Y Liang, Y Xing, M Esqueda… - PLoS neglected …, 2020 - journals.plos.org
Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans;
however, the underlying mechanisms are unclear. Here, we tested a hypothesis that …

Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice

Y Liang, J Fisher, C Gonzales, B Trent, G Card… - Frontiers in …, 2022 - frontiersin.org
Infection with Orientia tsutsugamushi, an obligate intracellular bacterium, can cause mild or
severe scrub typhus. Some patients develop acute lung injury, multi-organ failure, and fatal …

Revisiting scrub typhus: a neglected tropical disease

M Bhandari, RK Singh, A Laishevtcev… - … and Infectious Diseases, 2022 - Elsevier
Scrub typhus is an under diagnosed re-emerging vector borne disease caused by an
intracellular gram negative bacteria, Orientia. The disease is commonly prevalent in rural …

Prevalence and heterogeneity of antibiotic resistance genes in Orientia tsutsugamushi and other rickettsial genomes

RSP Rao, SD Ghate, RP Shastry, K Kurthkoti… - Microbial …, 2023 - Elsevier
Despite a million infections every year and an estimated one billion people at risk, scrub
typhus is regarded as a neglected tropical disease. The causative bacterium Orientia …