Berries are considered “promising functional fruits” due to their distinct and ubiquitous
therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …

Many male animals wield ornaments or weapons of exaggerated proportions. We propose
that increased cellular sensitivity to signaling through the insulin/insulin-like growth factor …

High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect
brain synaptic plasticity through impairment of insulin-sensitive processes underlying …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …

Mitochondria play a central role in the aging process. Studies in model organisms have
started to integrate mitochondrial effects on aging with the maintenance of protein …

Over the past decade, numerous reports have underscored the similarities between the
metabolism of Drosophila and vertebrates, with the identification of evolutionarily conserved …

Multicellular organisms live in environments containing diverse nutrients and a wide variety
of microbial communities. On the one hand, the immune response of organisms can protect …

Stress triggers cellular and systemic reactions in organisms to restore homeostasis. For
instance, metabolic stress, experienced during starvation, elicits a hormonal response that …

Insulin/IGF-like signalling (IIS) is an evolutionarily conserved pathway that has diverse
functions in multi-cellular organisms. Mutations that reduce IIS can have pleiotropic effects …