TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple
human cancer cells, although its frequency varies among different tumor types. Elevated …

Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA
TERRA. While TERRA expression is conserved through evolution, species-specific …

The tumor microenvironment (TME) plays a pivotal role in establishing malignancy, and it is
associated with high glycolytic metabolism and lactate release through monocarboxylate …

After leukemia, tumors of the brain and spine are the second most common form of cancer in
children. Despite advances in treatment, brain tumors remain a leading cause of death in …

Simple Summary A clinical test for alternative-lengthening-of-telomeres (ALT) could assist
with cancer diagnosis and monitoring of disease progression. ALT-targeted anticancer …

The foremost feature of glioblastoma (GBM), the most frequent malignant brain tumours in
adults, is a remarkable degree of intra-and inter-tumour heterogeneity reflecting the …

Dysregulation of alternative splicing of hTERT gene to generate full-length Htert (hTERT-FL)
that reactivate telomerase has been recognized as a major pathological alteration in …

Endometrial cancer (EC) is the commonest gynaecological malignancy. Current prognostic
markers are inadequate to accurately predict patient survival, necessitating novel prognostic …

Cancer genomes are characterized by the accumulation of small-scale somatic mutations as
well as large-scale chromosomal deletions, amplifications, and complex structural …