Neurological and psychiatric disorders are leading contributors to the global disease
burden, having a serious impact on the quality of life of both patients and their relatives …

Glutamate (Glu) is the principal excitatory neurotransmitter in the central nervous system. Its
receptors are classified into ionotropic receptors, which are ion channels and include …

Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

Apoptosis of nigral dopaminergic neurons by various mechanisms is an emerging
phenomenon involved in the degeneration of dopaminergic neurons in Parkinson's disease …

Huntington's disease (HD) is an autosomal fatal genetic disease in which degeneration of
neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are …

Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission
and are implicated in various neurological disorders. In this review, we discuss the role of …

Physical activity has been proposed as a behavior intervention that promotes mental health
and some of the benefits induced by exercise have been related to the glutamatergic …

The aim of this study was to analyze the plastic effects of moderate exercise upon the motor
cortex (M1 and M2 areas), cerebellum (Cb), and striatum (CPu) of the rat brain. This …

Glutamate, first identified in 1866, is the primary excitatory neurotransmitter in the brain.
While it is critically important in many highly regulated cortical functions such as learning …

In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-
type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory …