Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Metal–curcumin complexes in therapeutics: an approach to enhance pharmacological effects of curcumin

S Prasad, D DuBourdieu, A Srivastava… - International journal of …, 2021 - mdpi.com
Curcumin, an active component of the rhizome turmeric, has gained much attention as a
plant-based compound with pleiotropic pharmacological properties. It possesses anti …

Platinum (IV) and platinum (II) anticancer complexes with biologically active releasable ligands

P Štarha, R Křikavová - Coordination Chemistry Reviews, 2024 - Elsevier
The concept of multi-action octahedral platinum (IV) complexes is based on the rational
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …

Platinum (II) 5-substituted-8-hydroxyquinoline coordination compounds induces mitophagy-mediated apoptosis in A549/DDP cancer cells

Y Yang, LQ Du, Y Huang, CJ Liang, QP Qin… - Journal of Inorganic …, 2023 - Elsevier
For the first time, two new mononuclear platinum (II) coordination compounds,[Pt
(L1)(DMSO) Cl](PtL1) and [Pt (L2)(DMSO) Cl](PtL2) with the 5-(ethoxymethyl)-8 …

A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles

S Idoudi, Y Hijji, T Bedhiafi, HM Korashy, S Uddin… - Carbohydrate …, 2022 - Elsevier
Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility,
bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins …

BODIPY-attached zinc (II) complexes of curcumin drug for visible light assisted photo-sensitization, cellular imaging and targeted PDT

A Bhattacharyya, A Jameei, AA Karande… - European Journal of …, 2021 - Elsevier
Boron-dipyrromethene (BODIPY) based photosensitizers as porphyrinoids and curcumin as
natural product possess exciting photophysical features suitable for theranostic applications …

Biotin and boron-dipyrromethene-tagged platinum (IV) prodrug for cellular imaging and mito-targeted photocytotoxicity in red light

A Bera, A Nepalia, A Upadhyay, DK Saini… - Dalton …, 2023 - pubs.rsc.org
A platinum (IV) prodrug, cis, cis, trans-[Pt (NH3) 2Cl2 (biotin)(L)](1), derived from cisplatin,
where HL is the PEGylated red-light active boron-dipyrromethene (BODIPY) ligand, was …

BODIPY-tagged platinum (II) curcumin complexes for endoplasmic reticulum-targeted red light PDT

A Upadhyay, P Kundu, V Ramu, P Kondaiah… - Inorganic …, 2022 - ACS Publications
[Pt (RB)(Cur)] NO3 (RBC),[Pt (IRB)(Cur)] NO3 (IRBC), and [Pt (L)(Cur)] NO3 (PBC), where
HCur is curcumin, L is 1-benzyl-2-(2-pyridyl) benzimidazole, and RB and IRB are red-light …

Pt (II) versus Pt (IV) in carbene glycoconjugate antitumor agents: Minimal structural variations and great performance changes

A Annunziata, A Amoresano, ME Cucciolito… - Inorganic …, 2020 - ACS Publications
Octahedral Pt (IV) complexes (2Pt–R) containing a glycoconjugate carbene ligand were
prepared and fully characterized. These complexes are structural analogues to the trigonal …

Platin-C containing nanoparticles: a recipe for the delivery of curcumin–cisplatin combination chemotherapeutics to mitochondria

B Banik, A Ashokan, JH Choi, B Surnar, S Dhar - Dalton Transactions, 2023 - pubs.rsc.org
The success story of cisplatin spans over six decades now and yet it continues to be the key
player in most chemotherapeutic regimens. Numerous efforts have been made to improve its …