Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …

Light exerts a wide range of effects on mammalian physiology and behavior. As well as
synchronizing circadian rhythms to the external environment, light has been shown to …

Brief periods of sleep loss have long-lasting consequences such as impaired memory
consolidation. Structural changes in synaptic connectivity have been proposed as a …

Despite the ongoing fundamental controversy about the physiological function of sleep,
there is general consensus that sleep benefits neuronal plasticity, which ultimately supports …

Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …

Sleep deprivation is a public health epidemic that causes wide-ranging deleterious
consequences, including impaired memory and cognition. Protein synthesis in hippocampal …

Highlights•Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory
deficits.•Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep …

New memories are believed to be consolidated over several hours of post-task sleep. The
reactivation or “replay” of hippocampal cell assemblies has been proposed to provide a key …

Sleep problems are a common complaint in the majority of people suffering from depression.
While sleep complaints were traditionally seen as a symptom of mood disorders …

It is well established that sleep deprivation after learning impairs hippocampal memory
processes and can cause amnesia. It is unknown, however, whether sleep deprivation leads …