Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
Recent advances in triazoles as tyrosinase inhibitors
A Mermer, S Demirci - European Journal of Medicinal Chemistry, 2023 - Elsevier
The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a
significant position in melanogenesis, plays an important role in undesirable browning of …
significant position in melanogenesis, plays an important role in undesirable browning of …
Heterocyclic compounds as synthetic tyrosinase inhibitors: recent advances
Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders
U Ghani - European Journal of Medicinal Chemistry, 2022 - Elsevier
Azoles are a famous and promising class of drugs for treatment of a range of ailments
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …
Strategies for synthesis of 1, 2, 4-triazole-containing scaffolds using 3-amino-1, 2, 4-triazole
S Nasri, M Bayat, K Kochia - Molecular Diversity, 2022 - Springer
Triazole-containing scaffolds are unique heterocyclic compounds present in an array of
pharmaceuticals and biologically important compounds used in the drug-discovery studies …
pharmaceuticals and biologically important compounds used in the drug-discovery studies …
Biological and cheminformatics studies of newly designed triazole based derivatives as potent inhibitors against mushroom tyrosinase
A series of nine novel 1, 2, 4-triazole based compounds were synthesized through a
multistep reaction pathway and their structures were scrutinized by using spectral methods …
multistep reaction pathway and their structures were scrutinized by using spectral methods …
Elastase inhibitory activity of quinoline Analogues: Synthesis, kinetic mechanism, cytotoxicity, chemoinformatics and molecular docking studies
Herein, we have synthesized quinoline united various Schiff base derivatives (Q1-Q13) and
systematically characterized them using diverse analytical practices such as 1 H NMR, 13 C …
systematically characterized them using diverse analytical practices such as 1 H NMR, 13 C …
Synthesis, carbonic anhydrase inhibition, anticancer activity, and molecular docking studies of 1, 3, 4-oxadiazole derivatives
In this work, we have synthesized various organic compounds possessing 1, 3, 4-oxadiazole
as a core structure and the structure of the newly synthesized target compounds has been …
as a core structure and the structure of the newly synthesized target compounds has been …
Synthesis, properties and biological potential some condensed derivatives 1, 2, 4-triazole
A Gotsulya, T Brytanova - Journal of Faculty of Pharmacy of Ankara …, 2022 - dergipark.org.tr
Objective: The aim of the work was to develop effective methods for the synthesis of
biologically active heterocyclic systems containing pyrrole, indole and 1, 2, 4-triazole. In this …
biologically active heterocyclic systems containing pyrrole, indole and 1, 2, 4-triazole. In this …
Novel 1, 3, 4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies
In this research work, we have designed and synthesized some biologically useful of 1, 3, 4-
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …