Actin and actin-binding proteins
TD Pollard - Cold Spring Harbor perspectives in biology, 2016 - cshperspectives.cshlp.org
Organisms from all domains of life depend on filaments of the protein actin to provide
structure and to support internal movements. Many eukaryotic cells use forces produced by …
structure and to support internal movements. Many eukaryotic cells use forces produced by …
Molecular dynamics simulations of large macromolecular complexes
Connecting dynamics to structural data from diverse experimental sources, molecular
dynamics simulations permit the exploration of biological phenomena in unparalleled detail …
dynamics simulations permit the exploration of biological phenomena in unparalleled detail …
A nucleator arms race: cellular control of actin assembly
KG Campellone, MD Welch - Nature reviews Molecular cell biology, 2010 - nature.com
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …
promoting factors and formins were the only molecules known to directly nucleate actin …
The actin cytoskeleton as an active adaptive material
S Banerjee, ML Gardel… - Annual review of …, 2020 - annualreviews.org
Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …
their needs. Cellular adaptation is made possible by molecular processes that strongly …
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change
Summary Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
Characterization of two classes of small molecule inhibitors of Arp2/3 complex
BJ Nolen, N Tomasevic, A Russell, DW Pierce, Z Jia… - Nature, 2009 - nature.com
Polymerization of actin filaments directed by the actin-related protein (Arp) 2/3 complex
supports many types of cellular movements. However, questions remain regarding the …
supports many types of cellular movements. However, questions remain regarding the …
The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration
P Suraneni, B Rubinstein, JR Unruh, M Durnin… - Journal of Cell …, 2012 - rupress.org
The Arp2/3 complex nucleates the formation of the dendritic actin network at the leading
edge of motile cells, but it is still unclear if the Arp2/3 complex plays a critical role in …
edge of motile cells, but it is still unclear if the Arp2/3 complex plays a critical role in …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex
C Suarez, RT Carroll, TA Burke, JR Christensen… - Developmental cell, 2015 - cell.com
Fission yeast cells use Arp2/3 complex and formin to assemble diverse filamentous actin (F-
actin) networks within a common cytoplasm for endocytosis, division, and polarization …
actin) networks within a common cytoplasm for endocytosis, division, and polarization …
Actin and endocytosis in budding yeast
BL Goode, JA Eskin, B Wendland - Genetics, 2015 - academic.oup.com
Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …
essential for bringing many substances into the cell and for membrane turnover. The …