Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using
an established mouse model of lung cancer, we find that cachexia is characterized by …

Tumor tissue processing methodologies in combination with data‐independent acquisition
mass spectrometry (DIA‐MS) have emerged that can comprehensively analyze the …

Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Proteins are the molecular effectors of the information encoded in the genome. Proteomics
aims at understanding the molecular functions of proteins in their biological context. In …

Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in
response to replication stress. Here, we report that phosphorylation of the pivotal pathway …