An increased life span and accompanying nutritional affluency have led to a rapid increase
in diseases associated with aging, such as obesity and type 2 diabetes, imposing a …

The endoplasmic reticulum (ER) is the main site for protein synthesis, folding, and secretion,
and accumulation of the unfolded/misfolded proteins in the ER may induce ER stress. ER …

Regulated secretion, an essential cellular process, relies on secretory granules (SGs) for the
controlled release of a diverse range of cargo molecules, including proteins, peptides …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Pancreatic beta-cell death has been established as a critical mediator in the progression of
type 1 and type 2 diabetes mellitus. Beta-cell death is associated with exacerbating …

The pancreatic β-cell is purpose-built for the production and secretion of insulin, the only
hormone that can remove glucose from the bloodstream. Insulin is kept inside miniature …

The sorting of secreted cargo proteins and their export from the trans-Golgi network (TGN)
remains an enigma in the field of membrane trafficking; although the sorting mechanisms of …

Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

During development of type 2 diabetes (T2D), excessive nutritional load is thought to expose
pancreatic islets to toxic effects of lipids and reduce β-cell function and mass. However …

Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily
regulate glucose-stimulated insulin secretion in the pancreatic islet β-cell. The Rho family …