Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

MA Van Agtmael, TA Eggelte, CJ Van Boxtel - Trends in pharmacological …, 1999 - cell.com
Registration in Europe of several artemisinin drugs for the treatment of malaria can soon be
expected. Artemisinin is isolated from the herb Artemisia annua, in use in China more than …

History, dynamics, and public health importance of malaria parasite resistance

AO Talisuna, P Bloland… - Clinical microbiology …, 2004 - Am Soc Microbiol
Despite considerable efforts, malaria is still one of the most devastating infectious diseases
in the tropics. The rapid spread of antimalarial drug resistance currently compounds this …

Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine–pyrimethamine resistance in malaria-infected patients from …

CT Happi, GO Gbotosho, OA Folarin, DO Akinboye… - Acta tropica, 2005 - Elsevier
Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate
synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine …

Malaria: new developments in treatment and prevention

P Newton, BM, DPhil, MRCP… - Annual review of …, 1999 - annualreviews.org
Malaria still kills some 0.5–2.5 million people per year in the tropics. Resistance to the
cheap, most commonly used antimalarials continues to spread alarmingly and could …

[HTML][HTML] In vitro virucidal effect of intranasally delivered chlorpheniramine maleate compound against severe acute respiratory syndrome coronavirus 2

JB Westover, G Ferrer, H Vazquez… - Cureus, 2020 - ncbi.nlm.nih.gov
Background The initial global outbreak of the novel coronavirus disease 2019 (COVID-
2019) pandemic, which is responsible for the severe acute respiratory syndrome 2 (SARS …

Drug resistant falciparum malaria: clinical consequences and strategies for prevention

RN Price, F Nosten - Drug resistance updates, 2001 - Elsevier
The rising prevalence of multidrug resistant falciparum malaria is occurring at an alarming
rate and has serious implications for the health of many of the world's poorest countries. The …

Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs

A Sowunmi, BA Fateye - Tropical Medicine & International …, 2003 - Wiley Online Library
We evaluated gametocyte carriage and intensities of gametocytaemia in 710 children
presenting with acute, symptomatic, uncomplicated Plasmodium falciparum malaria who …

Chloroquine resistance reversal agents as promising antimalarial drugs

M Henry, S Alibert, E Orlandi-Pradines… - Current drug …, 2006 - ingentaconnect.com
The development and spread of resistance to antimalarial drugs poses a severe and
increasing public health threat. Failures of prophylaxis or treatment with quinolines …

Should chloroquine be laid to rest?

H Ginsburg - Acta tropica, 2005 - Elsevier
Chloroquine (CQ) has been the front line antimalarial drug due to its efficacy, low cost and
scanty side effects, until resistance has evolved. Although its use has been officially …

Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children

A Sowunmi, BA Fateye, AA Adedeji, FA Fehintola… - Parasitology, 2004 - cambridge.org
The risk factors associated with gametocytaemia at presentation and after treatment with
different antimalarial drug regimens were evaluated in 767 children enrolled prospectively in …