Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Neurodegenerative diseases (NDDs) encompass a range of conditions that involve
progressive deterioration and dysfunction of the nervous system. Some of the common …

Movement disorders are neurological conditions characterized by involuntary motor
movements, such as dystonia, ataxia, chorea myoclonus, tremors, Huntington's disease …

Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …

Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus
and stimulates the release of growth hormone (GH) in the anterior pituitary gland, which …

Huntington's Disease (HD) is a severe neurodegenerative disorder lacking effective
diagnostic and treatment options. However, there is increasing interest in the potential of …

Introduction Huntington's disease (HD) is a progressive neurodegenerative disorder caused
by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of …

Introduction Deutetrabenazine is approved for treatment of Huntington disease (HD)-related
chorea and tardive dyskinesia (TD) in adults. Factors associated with deutetrabenazine …

Deutetrabenazine is approved for the treatment of tardive dyskinesia and chorea associated
with Huntington's disease. This study compared the exposure between the once‐daily (test) …