Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but
also depends on mitochondrial pathways. Yet, how these two organelle systems …

In sporadic Alzheimer's disease (AD), impaired Aβ removal contributes to elevated
extracellular Aβ levels that drive amyloid plaque pathogenesis. Extracellular proteolysis …

ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially
understood despite the fact that environmental causes, risk factors, and specific gene …

Niemann-Pick type C1 (NPC) disease is a lysosomal storage disease caused by mutations
in the NPC1 gene, leading to an increase in unesterified cholesterol and several …